A target anti-acid drug, lower potential of drug interactions
Pantoprazole Enteric-coated (Pellets) Capsule is activated at the lowest pH of all the PPIs. This unique characteristic accounts for its particularly high tissue specificity. Pantoprazole is metabolized in the liver according to a pathway that is unique among PPIs because it involves both phase I and phase II biotransformation reactions. Of all the PPIs, Pantoprazole shows the lowest potential of drug interactions, and may therefore be co-administered with other drugs without the need to adjust the dosage of those drugs. Pantoprazole has linear pharmacokinetics after oral administration in the dose range of 10 to 80 mg. Pantoprazole shows a prompt and constant bioavailability of 77% from the very first dose. The pharmacokinetics of Pantoprazole are not influenced by the concomitant intake of antiacids or food. This means that the efficacy of the drug is the same whether it is taken with or without food and with or without other antacids.

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